< New Surgery-Free, Ultrasound Treatment for Brain Cancer Developed > (March 29)
- Researchers find possible applications in treatment dementia and other brain-related disorders with new drug-delivery method
The Ministry announced the development of a "new technology that enhances treatment by directly delivering chemotherapy medication to the cancerous region by opening the blood-brain barrier with ultrasound, circumventing the need for surgery."
The project was conducted by a team led by Dr. Park Ju-yeong of the Daegu-Gyeongbuk Medical Innovation Foundation with support from the ministry's Brain Science Research Program; the results of the study were publish in the March 28 issue of The Journal of Controlled Release (IF 7.441, top 3.52% in JCR), a world-leading pharmacology journal.
- Paper: Evaluation of permeability, doxorubicin delivery, and drug retention in a rat brain tumor model after ultrasound-induced blood-tumor barrier disruption.
Brain cancer is a serious disorder with a survival time of less than 15 months, usually treated with anticancer drugs but a difficult disease to treat due to the blood-brain barrier that prevents the effective delivery of drugs into the brain.
This study used a focused ultrasound method using animal models that enabled the opening of the blood-brain barrier without surgery, delivering doxorubicin, an FDA-approved chemotherapy drug directly to the cancerous region.
A comparison of the treatment group that received an injection of the anti-cancer drug after the blood-brain barrier was opened using ultrasound, and the control group, which received only a traditional injection, showed that more than three times the amount of the drug was delivered to the cancer site in the treatment group, with the drug remaining effective for more than 24 hours.
The results of the study may offer new methods of treating not only brain cancer but other diseases such as dementia through more effective drug delivery, offering a new solution for treating brain-related disorders that had been difficult to treat previously due to the blood-brain barrier.
Dr. Park said, "The study identified a new technology for enhancing the treatment efficacy of drugs that were previously left unused due to the inability to pierce the blood-brain barrier, despite their proven effectiveness," adding that "the breakthrough is especially significant for its potential application in drug treatment for dementia and other brain disorders."